ABSTRACT
The great advances in silicon photonic-sensing technology have made it an attractive platform for wide sensing applications. The small size of chip and detection system makes photonic microring resonator can be used in clinic for quick detection of disease. Here, we employ the high sensitivity of the photonic sensor toward the change of refractive index for the detection of SARS-CoV-2 virus spike proteins and botulinum toxin in water. The system require very small amount of sample 50uL with high sensitivity, in short 1hr without pre-treatment required. The measurement can be automatic with minimum manpower involved. Moreover, the system can be multiplexed to detect a few target analytes at the same time in one sample. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
ABSTRACT
To target the detection of intact SARS-COV-2 and its protein, research is focused on developing other diagnostic methods besides the molecular detection methods. Here, we employ the high sensitivity of the photonic sensor toward the change of refractive index for the detection of SARS-COV-2 virus spike proteins. The system require very small amount of sample 100uL with high sensitivity of 0.08 pM virus in short 60 min without pretreatment required. The measurement can be automatic with minimum manpower involved. Moreover, the system can be multiplexed to detect a few target analytes at the same time in one sample. © 2020 CBMS-0001